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تحميل كتاب Hematopoietic Stem Cell Protocols pdf
المؤلف : Christopher A Klug Craig T Jordan
عن الكتاب : تحميل كتاب Hematopoietic Stem Cell Protocols pdf تأليف Christopher A Klug Craig T Jordan pdf مجانا ... 2001م - 1443هـ
نبذه عن الكتاب:
Isolation and Analysis of Hematopoietic Stem Cells
from Mouse Embryos
Elaine Dzierzak and Marella de Bruijn
1. Introduction
Recently, there has been much interest in the embryonic origins of the adult
hematopoietic system in mammals (1). The controversy surrounding the
potency and function of hematopoietic cells produced by the yolk sac compared to those produced by the intrabody portion of the mouse embryo has
prompted much new research in the field of developmental hematopoiesis
(2–8). While the yolk sac is the first tissue in the mammalian conceptus to
visibly exhibit hematopoietic cells, the intrabody region—which at different
stages of development includes the splanchnopleural mesoderm, para-aortic
splanchnopleura (PAS) and the aorta-gonad-mesonephros (AGM) region—
clearly contains more potent undifferentiated hematopoietic progenitors and
stem cells before the yolk sac. Furthermore, the most interesting dichotomy
revealed by these studies is that terminally differentiated hematopoietic cells
can be produced in the mouse embryo before the appearance of cells with adult
repopulating capacity. Thus, the accepted view of the adult hematopoietic hierarchy with the hematopoietic stem cell (HSC) at its foundation does not reflect
the hematopoietic hierarchy in the developing mouse embryo (9). Because this
field offers many questions concerning the types of hematopoietic cells present
in the embryo, the lineage relationships between these cells, and the molecular
programs necessary for the development of the embryonic and adult hematopoietic systems, this section presents the approaches taken and the materials
and methods necessary to explore the mouse embryo for the presence of the
first adult repopulating HSCs. .
أعلان
عن الكتاب
تحميل كتاب Hematopoietic Stem Cell Protocols pdf تأليف Christopher A Klug Craig T Jordan pdf مجانا ... 2001م - 1443هـ
نبذه عن الكتاب:
Isolation and Analysis of Hematopoietic Stem Cells
from Mouse Embryos
Elaine Dzierzak and Marella de Bruijn
1. Introduction
Recently, there has been much interest in the embryonic origins of the adult
hematopoietic system in mammals (1). The controversy surrounding the
potency and function of hematopoietic cells produced by the yolk sac compared to those produced by the intrabody portion of the mouse embryo has
prompted much new research in the field of developmental hematopoiesis
(2–8). While the yolk sac is the first tissue in the mammalian conceptus to
visibly exhibit hematopoietic cells, the intrabody region—which at different
stages of development includes the splanchnopleural mesoderm, para-aortic
splanchnopleura (PAS) and the aorta-gonad-mesonephros (AGM) region—
clearly contains more potent undifferentiated hematopoietic progenitors and
stem cells before the yolk sac. Furthermore, the most interesting dichotomy
revealed by these studies is that terminally differentiated hematopoietic cells
can be produced in the mouse embryo before the appearance of cells with adult
repopulating capacity. Thus, the accepted view of the adult hematopoietic hierarchy with the hematopoietic stem cell (HSC) at its foundation does not reflect
the hematopoietic hierarchy in the developing mouse embryo (9). Because this
field offers many questions concerning the types of hematopoietic cells present
in the embryo, the lineage relationships between these cells, and the molecular
programs necessary for the development of the embryonic and adult hematopoietic systems, this section presents the approaches taken and the materials
and methods necessary to explore the mouse embryo for the presence of the
first adult repopulating HSCs. .
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