أعلان
تحميل كتاب Adhesion Protein Protocols Humana Press pdf
المؤلف : Elisabetta Dejana and Monica Corada
عن الكتاب : 1999م - 1443هـ
نبذه عن الكتاب:
The specificity, homogeneity, and ability to be produced in unlimited
amounts have made monoclonal antibodies (MAbs) an extremely useful tool
for the study of a great variety of molecules involved in cellular adhesion phenomena. In many cases, the detailed biochemical and functional characterization of members of the integrin, selectin, immunoglobulin, and cadherin
families of adhesion receptors, and their specific cellular and tissue distribution have only been made possible through the development and use of specific
MAbs to these molecules.
Very often, the binding of a MAb to a membrane receptor involved in cell
adhesion affects the function of the molecule, and results in inhibition or
enhancement of the ability of the cell to adhere to the specific ligand. These
functional effects of MAbs usually reflect a direct or physical involvement of
the epitope recognized in ligand interaction; in other cases, however, the functional effects exerted by MAbs can only be explained through the induction of
conformational changes in the adhesion receptor. Those MAbs that reduce the
ability of an adhesion molecule to interact with specific ligands are usually
referred to as “blocking” or “inhibitory” antibodies. Conversely, those MAbs
that are able to enhance the interaction of an adhesion receptor with its ligand
are generally termed “activating” or “stimulatory” antibodies. A third group of
.
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وصف كتاب Adhesion Protein Protocols Humana Press
1999م - 1443هـ
نبذه عن الكتاب:
The specificity, homogeneity, and ability to be produced in unlimited
amounts have made monoclonal antibodies (MAbs) an extremely useful tool
for the study of a great variety of molecules involved in cellular adhesion phenomena. In many cases, the detailed biochemical and functional characterization of members of the integrin, selectin, immunoglobulin, and cadherin
families of adhesion receptors, and their specific cellular and tissue distribution have only been made possible through the development and use of specific
MAbs to these molecules.
Very often, the binding of a MAb to a membrane receptor involved in cell
adhesion affects the function of the molecule, and results in inhibition or
enhancement of the ability of the cell to adhere to the specific ligand. These
functional effects of MAbs usually reflect a direct or physical involvement of
the epitope recognized in ligand interaction; in other cases, however, the functional effects exerted by MAbs can only be explained through the induction of
conformational changes in the adhesion receptor. Those MAbs that reduce the
ability of an adhesion molecule to interact with specific ligands are usually
referred to as “blocking” or “inhibitory” antibodies. Conversely, those MAbs
that are able to enhance the interaction of an adhesion receptor with its ligand
are generally termed “activating” or “stimulatory” antibodies. A third group of
.
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