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تحميل كتاب Blagosklonny Cell Cycle Checkpoints and Cancer Landes Bioscience 2001 pdf
المؤلف : Mikhail V Blagosklonny Bethesda Maryland U S A
عن الكتاب : 2001م - 1443هـ نبذه عن الكتاب:
Autocrine Transformation: Cytokine Model .......................................... 1
James A. McCubrey, Xiao-Yang Wang, Paul A. Algate,
William L. Blalock and Linda S. Steelman
Abstract ................................................................................................. 1
Cytokine Regulation of Growth ............................................................ 1
2. Signal Transduction Pathways:
Cytokine Model ................................................................................... 17
James A. McCubrey, William L. Blalock, Fumin Chang,
Linda S. Steelman, Steven C. Pohnert, Patrick M. Navolanic,
John G. Shelton, Paul E. Hoyle, Phillip W. Moye,
Stephanie M. Oberhaus, Martyn K. White, John T. Lee
and Richard A. Franklin
Abstract ............................................................................................... 17
Cytokine-Induced Signal Transduction Resulting in Growth
and the Prevention of Apoptosis ...................................................... 17
Adaptor Proteins that Couple Receptors
with Downstream Pathways ............................................................ 19
The Jak-STAT Pathway ...................................................................... 19
The PI3K/Akt Pathway ....................................................................... 22
The Ras/Raf/MEK/ERK Signal Transduction Pathway ....................... 22
The Ras/Raf/MEK/ERK Pathway: Downstream Kinase Activation ..... 26
Interactions Between the Raf/MEK/ERK
and the PI3K/Akt Pathways ............................................................ 28
The Ras/Raf/MEK/ERK Pathway: A Tether Enhancing Signal
Transduction ................................................................................... 28
The Ras/Raf/MEK/ERK Pathway: Regulation of Downstream
Transcription Factors ...................................................................... 28
Induction of Autocrine Gene Expression by Altered Raf/MEK
and PI3K/Akt Expression ................................................................ 29
Mutations of Ras/Raf/MEK/ERK Cascade
which Result in Neoplasia ............................................................... 29
Regulatory Phosphatases of the Ras/Raf/MEK/ERK Pathway.............. 29
Alternative MAPK Pathways Activated by Stress ................................. 31
Default Pathways which Dampen Signaling ........................................ 31
Jak/STAT Inhibitors ........................................................................... 33
PI3K/p70S6K Inhibitors ..................................................................... 33
Ras/Raf/MEK/ERK Pathway Inhibitors .............................................. 33
PKC Inhibitors ................................................................................... 33
Cytokine Regulation of Cell Cycle Progression ................................... 34
Links Between the Ras/Raf/MEK/ERK Pathway
and Cell Cycle Proteins ................................................................... 34
Cytokine Regulation of Apoptosis and Cell Death .............................. 34
Apoptotic Mediators: The Caspases ..................................................... 34
.
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وصف كتاب Blagosklonny Cell Cycle Checkpoints and Cancer Landes Bioscience 2001
2001م - 1443هـ نبذه عن الكتاب:
Autocrine Transformation: Cytokine Model .......................................... 1
James A. McCubrey, Xiao-Yang Wang, Paul A. Algate,
William L. Blalock and Linda S. Steelman
Abstract ................................................................................................. 1
Cytokine Regulation of Growth ............................................................ 1
2. Signal Transduction Pathways:
Cytokine Model ................................................................................... 17
James A. McCubrey, William L. Blalock, Fumin Chang,
Linda S. Steelman, Steven C. Pohnert, Patrick M. Navolanic,
John G. Shelton, Paul E. Hoyle, Phillip W. Moye,
Stephanie M. Oberhaus, Martyn K. White, John T. Lee
and Richard A. Franklin
Abstract ............................................................................................... 17
Cytokine-Induced Signal Transduction Resulting in Growth
and the Prevention of Apoptosis ...................................................... 17
Adaptor Proteins that Couple Receptors
with Downstream Pathways ............................................................ 19
The Jak-STAT Pathway ...................................................................... 19
The PI3K/Akt Pathway ....................................................................... 22
The Ras/Raf/MEK/ERK Signal Transduction Pathway ....................... 22
The Ras/Raf/MEK/ERK Pathway: Downstream Kinase Activation ..... 26
Interactions Between the Raf/MEK/ERK
and the PI3K/Akt Pathways ............................................................ 28
The Ras/Raf/MEK/ERK Pathway: A Tether Enhancing Signal
Transduction ................................................................................... 28
The Ras/Raf/MEK/ERK Pathway: Regulation of Downstream
Transcription Factors ...................................................................... 28
Induction of Autocrine Gene Expression by Altered Raf/MEK
and PI3K/Akt Expression ................................................................ 29
Mutations of Ras/Raf/MEK/ERK Cascade
which Result in Neoplasia ............................................................... 29
Regulatory Phosphatases of the Ras/Raf/MEK/ERK Pathway.............. 29
Alternative MAPK Pathways Activated by Stress ................................. 31
Default Pathways which Dampen Signaling ........................................ 31
Jak/STAT Inhibitors ........................................................................... 33
PI3K/p70S6K Inhibitors ..................................................................... 33
Ras/Raf/MEK/ERK Pathway Inhibitors .............................................. 33
PKC Inhibitors ................................................................................... 33
Cytokine Regulation of Cell Cycle Progression ................................... 34
Links Between the Ras/Raf/MEK/ERK Pathway
and Cell Cycle Proteins ................................................................... 34
Cytokine Regulation of Apoptosis and Cell Death .............................. 34
Apoptotic Mediators: The Caspases ..................................................... 34
.
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