Name: In silico simulation of biological processes
Author: John Wiley

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المؤلف : John Wiley

التصنيف : الكتب العلمية

الفئة : علم الأحياء

سنة النشر : 2002

عدد الصفحات : غير محدد

عن الكتاب : 2002م - 1443هـ نبذه عن الكتاب: This meeting establishes a major landmark since it is the ¢rst fully published meeting on the growing ¢eld of computer (in silico) representation of biological processes. The ¢rst International Conference on Computational Biology was held earlier in 2001 (Carson et al 2001) but was not published. Various funding bodies (INSERM, MRC and NIH) have held strategy meetings, also unpublished. And there is a lot of interest in the industrial world of pharmaceutical, biotechnology and medical device companies. Now is the ripe time to explore the issues in depth. That is the purpose of this meeting. The Novartis Foundation has already played a seminal role in the thinking that forms the background to our discussions. Two previous meetings were fertile breeding grounds for the present one. The ¢rst was on The limits of reductionism in Biology(Novartis Foundation 1998), proposed and chaired by Lewis Wolpert. That meeting set the scene for one of the debates that will feature again in this meeting, which is the issue of reduction versus integration. There cannot be any doubt that most of the major successes in biological research in the last few decades have come from the reductionist agenda attempting to understand biological processes entirely in terms of the smallest entities, i.e. genes, proteins and other macromolecules, etc. We have, successfully, broken Humpty Dumpty down into his smallest bits. Do we now have to worry about how to put him back together again? That is the agenda of integration, and most of the people I have spoken to believe that this absolutely requires simulation in order to succeed. I also suggest that there needs to be a constructive tension between reduction and integration. Neither alone gives the complete story. .

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كتاب In silico simulation of biological processes

2002م - 1443هـ نبذه عن الكتاب: This meeting establishes a major landmark since it is the ¢rst fully published meeting on the growing ¢eld of computer (in silico) representation of biological processes. The ¢rst International Conference on Computational Biology was held earlier in 2001 (Carson et al 2001) but was not published. Various funding bodies (INSERM, MRC and NIH) have held strategy meetings, also unpublished. And there is a lot of interest in the industrial world of pharmaceutical, biotechnology and medical device companies. Now is the ripe time to explore the issues in depth. That is the purpose of this meeting. The Novartis Foundation has already played a seminal role in the thinking that forms the background to our discussions. Two previous meetings were fertile breeding grounds for the present one. The ¢rst was on The limits of reductionism in Biology(Novartis Foundation 1998), proposed and chaired by Lewis Wolpert. That meeting set the scene for one of the debates that will feature again in this meeting, which is the issue of reduction versus integration. There cannot be any doubt that most of the major successes in biological research in the last few decades have come from the reductionist agenda attempting to understand biological processes entirely in terms of the smallest entities, i.e. genes, proteins and other macromolecules, etc. We have, successfully, broken Humpty Dumpty down into his smallest bits. Do we now have to worry about how to put him back together again? That is the agenda of integration, and most of the people I have spoken to believe that this absolutely requires simulation in order to succeed. I also suggest that there needs to be a constructive tension between reduction and integration. Neither alone gives the complete story. .

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